Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 2, Pages 255-258Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm010400c
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Funding
- NCI NIH HHS [P30CA16056, CA 55791] Funding Source: Medline
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The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of H-3-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.
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