Journal
TETRAHEDRON LETTERS
Volume 43, Issue 4, Pages 557-559Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)02218-3
Keywords
oxazolidinones; hydrolysis; amino alcohols; solid supported reagents/reactions
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We have developed two convenient methods for hydrolysis of 2-oxazolidinones to the corresponding vicinal aminoalcohols. N-Substituted oxazolidinones can be readily hydrolyzed using Dowex 1x8-100 resin. N-Unsubstituted oxazolidiilones cannot be hydrolyzed using Dowex resins but are effectively hydrolyzed using polymer supported ethylenediamine. (C) 2002 Published by Elsevier Science Ltd.
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