Journal
ONCOGENE
Volume 21, Issue 4, Pages 619-626Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205061
Keywords
telomeres; telomerase; chromosomal instability
Funding
- NIGMS NIH HHS [GM43080] Funding Source: Medline
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Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.
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