Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 195, Issue 2, Pages 269-275Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20010670
Keywords
homing; migration; chemokine; B cell; isotype
Categories
Funding
- NIAID NIH HHS [5 T32 AI07290, R01 AI047822, R21 AI047822, T32 AI007290, 5R37AI121362-16, AI37832, R37 AI047822, AI47822] Funding Source: Medline
- NIDDK NIH HHS [F32 DK010022, DK10022] Funding Source: Medline
- NIGMS NIH HHS [R01 GM037734, R37 GM037734, GM37734] Funding Source: Medline
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Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells front spleen, Peyer's patches, and mesenteric lymph node. Cells secreting IgA antibody in response to rotavirus, an intestinal pathogen, also respond well. In contrast. IgG- and IgM-ASC respond poorly. Epithelial cells in the small intestines, a principal site of IgA-ASC localization and IgA production in the body, highly and selectively express TECK. The migration of IgA-ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response.
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