Journal
SCIENCE
Volume 295, Issue 5555, Pages 686-690Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1066642
Keywords
-
Categories
Funding
- NCRR NIH HHS [R24 RR012596, RR12596] Funding Source: Medline
- NIH HHS [R24 OD010943] Funding Source: Medline
- NINDS NIH HHS [5F32NS11107-02] Funding Source: Medline
Ask authors/readers for more resources
During development, neurons extend axons along defined routes to specific target cells. We show that additional mechanisms ensure that axons maintain their correct positioning in defined axonal tracts. After termination of axonal outgrowth and target recognition, axons in the ventral nerve cord (VNC) of Caenorhabditis elegans require the presence of a specific VNC neuron, PVT, to maintain their correct positioning in the left and right fascicles of the VNC. PVT may exert its stabilizing function by the temporally tightly controlled secretion of 2-immunoglobulin (Ig)-domain proteins encoded by the zig genes. Dedicated axon maintenance mechanisms may be widely used to ensure the preservation of functional neuronal circuitries.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available