Journal
TETRAHEDRON LETTERS
Volume 43, Issue 5, Pages 843-846Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)02251-1
Keywords
polyketides; naphthalene; fungi; chimera; biosynthesis
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Aspergillus nidulans wA and Colletotrichum lagenarium pks1 code for iterative type I polyketide synthases (PKSs) and synthesize heptaketide naphthopyrone and pentaketide naphthalene, respectively. A chimeric PKS, called SW-B, composed of WA and PKS1 synthesized mainly hexaketide isocoumarin and all unknown yellow compound. The latter was identified as the novel hexaketide 2-acetyl-1,3,6,8-tetrahydroxynaphthalene. These findings indicate broad substrate specificity of the WA C-terminal domain for Claisen-type cyclization and an unprecedented chain length determination mechanism of fungal aromatic PKSs. (C) 2002 Elsevier Science Ltd. All rights reserved.
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