Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 643, Issue -, Pages 381-391Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(01)01238-4
Keywords
alkyl hypophosphite; aminoalkylphosphinic acids; kabachnik-fields reaction; Michael addition; phosphinopeptides
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A simple and effective preparation of phosphinodipeptides, in good overall yields, has been developed, This one pot procedure, allowing the variation of the substituents in alpha and/or beta position to the phosphorus atom and also in alpha position to the nitrogen atom, consists in the addition of alkyl hypophosphites to imines. followed by Michael-addition on acrylates. To show the value of phosphinodipeptides analogs I as synthetic intermediates, selective deprotections of the three functional groups are described. (C) 2002 Elsevier Science B.V. All rights reserved.
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