Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 12, Issue 1, Pages 89-97Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(02)00294-4
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Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.
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