Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 49, Issue 2, Pages 327-330Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/49.2.327
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In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Deltalog(10) cfu/mL.h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 +/- 0.14 Deltalog(10) cfu/mL.h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.
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