Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 13, Issue 1, Pages 27-40Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(01)00023-5
Keywords
interleukin-2 receptor (IL-2R); Jak3; phosphatidylinositol 3 kinase (PI3K)
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Interleukin-2 (IL-2) plays a major role in the proliferation of cell populations during an immune reaction. The beta(c) and gamma(c) subunits of the IL-2 receptor (IL-2R) are sufficient and necessary for signal transduction. Despite lacking known catalytic domains, receptor engagement leads to the activation of a diverse array protein tyrosine kinases (PTKs). In resting or anergised T cells, Jak3 is not activated. Signals arising from the PROX domain of the gamma(c) subunit activate p56(lck) (lck) leading to the induction of anti-apoptotic mechanisms. When Jak3 is activated, in primed T cells, other PTKs predominately mediate the induction of anti-apoptotic mechanisms and drive cellular proliferation. This review intends to suggest a role for these differences within the context of the immune system. (C) 2002 Published by Elsevier Science Ltd.
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