Journal
MOLECULAR NEUROBIOLOGY
Volume 25, Issue 1, Pages 1-17Publisher
SPRINGER
DOI: 10.1385/MN:25:1:001
Keywords
complement; innate immunology; inflammation; neurodegeneration; CNS infection; therapy
Categories
Ask authors/readers for more resources
Complement is an important component off the innate immune response with the capacity to recognize and clear infectious challenges that invade the CNS through a damaged blood brain barrier. For instance, the membrane attack complex is involved in cytotoxic and cytolytic activities while other smaller fragments lead to cell activation (chemotaxis) and phagocytosis of the intruders. It is noteworthy that there is a growing body of evidence that uncontrolled complement biosynthesis and activation in the CNS can contribute to exacerbate the neuronal loss in several neurodegenerative disorders. We provide here an insightful review of the double-edged sword activities of the local innate complement system in the CNS and discuss further the potential therapeutic avenues of delivering complement inhibitors to control brain inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available