One-pot preparation of chiral β-amino esters by rhodium-catalyzed three-components coupling reaction

Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatasky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imine prepared in situ.