Journal
ACTA ANAESTHESIOLOGICA SCANDINAVICA
Volume 46, Issue 2, Pages 194-198Publisher
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1399-6576.2002.460213.x
Keywords
analgesics, non-opioid, ketoprofen; analgesics, opioid, sufentanil; anesthesia combined spinal-epidural; child; controlled clinical trial; dosage forms; injection; ketoprofen; pharmacokinetics
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Background: No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children. Methods: We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months to 16 years. Venous blood samples were collected at 5 min, 1, 2, 4, 24 following the loading dose, and then 1, 2 and 4h after the end of the infusion. A validated HPLC method was used to measure plasma levels of ketoprofen. Results: The steady state plasma concentration of ketoprofen was 2.0 mug/mL (range 1.3-2.7 mug/mL). The clearance of ketoprofen was 0.09L.h(-1).kg(-1) (range 0.06-0.13L-h(-1).kg(-1)). The distribution volume was 0.16L/kg (range 0.12-0.21L/kg). The terminal half-life was 1.3h (range 0.8-1.7h). Conclusion: The pharmacokinetics of ketopofen in children is similar to that reported in adults. Our results indicate that ketoprofen is a feasible drug for continuous intravenous infusion in acute pain treatment in children.
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