Journal
AGEING RESEARCH REVIEWS
Volume 1, Issue 1, Pages 61-77Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0047-6374(01)00364-5
Keywords
Alzheimer's disease; vascular disease; epidemiology; risk factors
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Alzheimer's disease (AD) is the most frequent type of dementia in old age. The pathology of AD is not well understood. One hypothesis states that AD has a vascular basis. This hypothesis is controversial because AD has traditionally been studied and treated as a separate disease from vascular dementia. This article reviews the epidemiologic evidence supporting an association between AD and two major vascular risk factors-blood pressure and diabetes. Both methodologic and biologic explanations for these associations are discussed. Published by Elsevier Science Ireland Ltd.
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