Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 22, Issue 2, Pages 329-334Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/hq0202.104122
Keywords
platelet adhesion; von Willebrand factor; glycoprotein Ib; shape changes; high shear rate
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Recent studies have revealed that the platelet adhesive process under flow is tightly regulated by multiple ligand-receptor interactions. However. platelet morphological changes during this process. particularly its physiological relevance, remain unknown under blood flow conditions. Using epifluorescence and scanning electron microscopy, we evaluated the real-time changes in platelet morphology during a platelet adhesive process on a von Willebrand factor-coated surface under physiological high shear flow in a perfusion chamber. Here, we show that dynamic platelet shape changes occurring during distinct phases of the adhesive process are precisely regulated by inside-out and outside-in integrin signals and are also a key regulatory element in successful platelet thrombogenesis opposing rapid blood flow in vivo.
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