Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 2, Issue 1, Pages 76-81Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4892(02)00124-8
Keywords
-
Categories
Ask authors/readers for more resources
G-protein-coupled receptors such as opioid receptors exist in oligomeric complexes. Homo-oligomerization of mu, delta, and kappa opioid receptors has been demonstrated, suggesting a critical functional role for receptor-receptor interactions. Hetero-oligomerization creates delta-kappa and mu-delta receptor complexes, which display novel pharmacology, coupling to effector systems and signaling regulation properties. Exciting new opportunities are arising from the recent characterization of these oligomeric receptors, with the potential to revolutionize opioid research and therapeutic targeting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available