Journal
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Volume 14, Issue 2, Pages 103-105Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00042737-200202000-00002
Keywords
anti-Saccharomyces cerevisiae mannan antibodies; Crohn's disease; inflammatory bowel disease; perinuclear antineutrophil cytoplasmic autoantibodies; ulcerative colitis
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Accurate serological assays are desirable for the diagnosis of inflammatory bowel disease. Among several serological markers anti-Saccharomyces cerevisiae mannan antibodies and perinuclear antineutrophil cytoplasmic autoantibodies are highly disease specific for Crohn's disease and ulcerative colitis, respectively. Combining the two improves their specificity. Sensitivity, however, is still low. Due to lack of standardization and vast interobserver variability, they cannot be used as the only diagnostic criteria but can assist clinicians in diagnosing and categorizing patients with inflammatory bowel disease as well as in helping them to take therapeutic decisions. Eur J Gastroenterol Hepatol 14:103-105 (C) 2002 Lippincott Williams Wilkins.
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