Journal
JOURNAL OF MASS SPECTROMETRY
Volume 37, Issue 2, Pages 216-222Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jms.277
Keywords
liquid chromatography/mass spectrometry; alkaloids; voacamine; malaria; plant extracts
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Four alkaloids were isolated from an alcoholic extract of the bark from the stem of Peschiera fuschiaefolia. Two of these compounds, voacamine and voacamidine, are dimeric alkaloids which are thought to be responsible for the antimalarial activity of these extracts. The mass spectra and the response factors of these four compounds were obtained by liquid chromatography/mass spectrometry in the electrospray positive ionization mode. The concentrations of these alkaloids were measured in two different A fuschiaefolia folia extracts. The ion chromatograms of the two extracts were compared on the basis of their [M + H](+) and [M + 2H](+2) ions characteristic of various alkaloids previously isolated from P. fuschiaefolia bark. The two extracts were found to differ mostly in the relative concentrations of the dimeric alkaloids. Copyright (C) 2002 John Wiley Sons, Ltd.
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