Journal
VISION RESEARCH
Volume 42, Issue 4, Pages 401-415Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(01)00214-0
Keywords
phototransduction; light adaptations; transgenic mice; transducin; arrestin
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Two genetically engineered strains of mice were used to characterize murine cone function electroretinographically, without interference of rod-driven responses: ( 1) mice with a deletion of the gene for the rod transducin alpha-subunit (transducin alpha-/-) and (2) mice with rod arrestin deleted (arrestin -/-). In the first three months of age, both strains have a normal complement of rods and normal rod structure, but transducin alpha-/- mice have no rod-driven responses to light, while rod-driven activity of arrestin -/- mice can be suppressed by a single intense flash for hours. In response to intense flashes the electroretinograms of these strains of mice showed a readily identifiable, pure-cone a-wave of similar to10 muV saturating amplitude. A 530 nm background that saturates rod responses of wild type mice was found to desensitize the b-wave responses of mice of both transgenic lines. whether the b-waves were driven by photons captured by M- or UV-cone pigments. The desensitizing effect of the 530 nm background on UV-pigment driven responses provides new evidence in support of the hypothesis of functional co-expression of the M-pigment in cones expressing primarily the UV-pigment. (C) 2002 Published by Elsevier Science Ltd.
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