Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 50, Issue 2, Pages 208-215Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.50.208
Keywords
Myrica rubra; degranulation inhibitor; RBL-2H3 cell; (+)-S-myricanol 5-O-beta-D-glucopyranoside; myricanene A 5-O-alpha-L-arabinofuranosyl(l -> 6)-beta-D-glucopyranoside; myricanene B5-O-alpha-L-arabinofuranosyl(l -> 6)-beta-D-glucopyranoside
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Three new diarylheptanoid glycosides, named (+)-S-myricanol 5-O-beta-D-glucopyranoside, myricanene A 5-O-alpha-L-arabinofuranosyl(1-->6)-beta-D-glucopyranoside, and myricanene B 5-O-alpha-L-arabinofuranosyl(1-->6)-beta-D-glucopyranoside, were Isolated from the bark of Chinese Myrica rubra, together with twenty known compounds. The absolute stereostructures of the new diarylheptanoid glycosides were elucidated on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method. The inhibitory effects of isolated constituents on the release of beta-hexosaminidase from RBL-2H3 cells were examined, and several diaryl-heptanoids, myricanol, (+)-S-myricanol, myricanone, and myricanenes A and B, and a flavonol, myricetin, were found to show the inhibitory activity.
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