Journal
PEPTIDES
Volume 23, Issue 2, Pages 383-388Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(01)00615-5
Keywords
peptide YY; receptor; growth; epidermal growth factor receptor; mitogen-activated protein kinase; epithelium
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Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY. PYY induces proliferation in intestinal cells in vivo and in vitro. and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth. (C) 2002 Elsevier Science Inc. All rights reserved.
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