Journal
JOURNAL OF ANTIBIOTICS
Volume 55, Issue 2, Pages 155-164Publisher
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.55.155
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Two novel compounds, stachyflin and acetylstachyflin, have been isolated by solid-state fermentation of Stachybotrys sp. RF-7260. The structures of both metabolites, determined by detailed NMR analyses and X-ray crystallographic analysis, are novel with a pentacyclic moiety including cis-fused decalin. The absolute stereochemistry of stachyflins was determined by circular dichroism analysis. Stachyflin showed antiviral activity against influenza A virus (H1N1) in vitro with an IC50 value of 0.003 mum. Acetylstachyflin was about 77-fold less active than stachyflin.
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