Journal
NATURE GENETICS
Volume 30, Issue 2, Pages 147-148Publisher
NATURE AMERICA INC
DOI: 10.1038/ng824
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- NIDDK NIH HHS [K08 DK062100] Funding Source: Medline
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Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).
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