Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 3, Issue 2, Pages 94-103Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm729
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Funding
- NIGMS NIH HHS [R01 GM034478, R37 GM034478] Funding Source: Medline
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The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing and transport of neurotransmitters, as well as the entry of many viruses into cells, The transporters responsible for controlling this crucial parameter in many intracellular compartments are the vacuolar (H+)-ATPases (V-ATPases). Recent advances in our understanding of the structure and regulation of the V-ATPases, together with the mapping of human genetic defects to genes that encode V-ATPase subunits, have led to tremendous excitement in this field.
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