Journal
CHEST
Volume 121, Issue 2, Pages 621-624Publisher
AMER COLL CHEST PHYSICIANS
DOI: 10.1378/chest.121.2.621
Keywords
airway hyperresponsiveness; airway smooth muscle; asthma; calcium
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We propose that abnormal calcium handling by the airway smooth muscle may be an important determinant of airway hyperresponsiveness. The amplitude, frequency, or localization of Ca2+ oscillations in the smooth muscle may determine the degree of airway sensitivity and reactivity, which are characteristic features of asthma.
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