Journal
DEVELOPMENTAL CELL
Volume 2, Issue 2, Pages 195-206Publisher
CELL PRESS
DOI: 10.1016/S1534-5807(02)00114-4
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM49869] Funding Source: Medline
Ask authors/readers for more resources
Polarization of the one-cell C. elegans embryo establishes the animal's anterior-posterior (a-p) axis. We have identified reduction-of-function anaphase-promoting complex (APC) mutations that eliminate a-p polarity. We also demonstrate that the APC activator cdc20 is required for polarity. The APC excludes PAR-3 from the posterior cortex, allowing PAR-2 to accumulate there. The APC is also required for tight cortical association and posterior movement of the paternal pronucleus and its associated centrosome. Depletion of the protease separin, a downstream target of the APC, causes similar pronuclear and a-p polarity defects. We propose that the APC/separin pathway promotes close association of the centrosome with the cortex which in turn excludes PAR-3 from the posterior pole early in a-p axis formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available