Journal
DIAGNOSTIC CYTOPATHOLOGY
Volume 26, Issue 2, Pages 95-98Publisher
WILEY-LISS
DOI: 10.1002/dc.10047
Keywords
fibrolamellar hepatocellular carcinoma; fine needle aspiration; oncocyte
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We report a case of fibrolamellar hepatocellular carcinoma (FL-HCC) that metastasized to the posterior mediastinum. The diagnosis was made on fine-needle aspiration biopsy (FNAB). The cytologic features were characterized by, the presence of large, dishesive, polygonal cells with granular cytoplasm and well-defined cell outlines resembling oncocytes. Groups of neoplastic hepatocytes containing bile pigment were also noted. The diagnosis of FL-HCC in a metastatic site can pose diagnostic challenges on FNAB. The cytologic features overlap with a variety of tumors that have oncocytic features and also with melanoma and paraganglioma. Recognition of specific cytologic features of FL-HCC can facilitate accurate diagnosis in a metastatic site. The cytologic findings and differential diagnoses of FL-HCC that metastasized to the posterior mediastinum are discussed. Diagn. Cytopathol. 2002;26:95-98; DOI 10.1002/dc.10047 (C) 2002 Wiley-Liss, Inc.
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