Journal
JOURNAL OF IMMUNOLOGY
Volume 168, Issue 3, Pages 996-1000Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.3.996
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STAT6 plays an important role in IL-4-mediated B cell activation and differentiation. To identify primary and secondary target genes of STAT6, gene expression profiles of IL-4-stimulated B cells from STAT6(+/+) vs STAT6(-/-) mice were compared. Statistical analysis revealed that 106 distinct probe sets including 70 known genes were differentially expressed between the 2 genotypes. These genes include transcription factors, kinases, and other enzymes, cell surface receptors, and Ig H chains. Surprisingly, although 31 genes were expressed at higher levels in STAT6(+/+) B cells, 39 genes were expressed at higher abundance in STAT6(-/-) B cells. This result implies both positive and negative regulatory functions of STAT6 in IL-4-mediated gene expression. Furthermore, IL-4 induces expression of the transcription factor Krox20, which is required for maximal IL-4-induced transcription.
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