Journal
CLINICAL IMMUNOLOGY
Volume 102, Issue 2, Pages 117-134Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/clim.2001.5143
Keywords
superantigen; repertoire; tolerance; protein A; immunotherapy; virulence factor; VH region; Fab binding; Ig-binding protein
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Funding
- NIAID NIH HHS [AI46637, AI40305] Funding Source: Medline
- NIAMS NIH HHS [P30 AR47360, AR40770] Funding Source: Medline
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Recent reports have shown that protein A of Staphylococcus aureus (SpA) is a specific toxin for B cells by virtue of specific binding interactions with conserved sites on the V-H region of the B-cell antigen receptor. The structural basis for these Fab-binding interactions has recently been revealed in crystallographic analyses, which have demonstrated many similarities with the interactions of T-cell superantigens. Investigations of the in vivo response to SpA have illustrated how a B-cell superantigen can be used to provide a window for examining fundamental principles that underlie the immunobiology of B lymphocytes. (C) 2001 Elsevier Science (USA).
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