Journal
MECHANISMS OF DEVELOPMENT
Volume 111, Issue 1-2, Pages 159-162Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00602-5
Keywords
Gata-2; sex determination; gonad development; mouse; ovary
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Funding
- Medical Research Council [MC_U142684167] Funding Source: Medline
- MRC [MC_U142684167] Funding Source: UKRI
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We report that Gata-2 is expressed in a sexually dimorphic fashion during mouse gonadogenesis. Gata-2 transcripts accumulate rapidly in the fetal ovary from 11.5 days post coitum (dpc) onwards, but are not detected in the fetal testis throughout the period studied (10.5-15.5 dpc). Ovarian expression of Gata-2 ceases by 15.5 dpc. Examination of ovaries from embryos homozygous for the extreme allele of c-kit(W-e) (Nature, 335, 88; Cell, 55, 185) demonstrates that ovarian Gata-2 expression is dependent upon the presence of germ cells. Comparative in situ hybridisation using the germ cell marker Oct4 (EMBO J., 8, 2543) indicates that Gata-2 transcripts are restricted to the germ cell lineage at 13.5 dpc. (C) 2002 Elsevier Science Ireland Ltd. All lights reserved.
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