Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 109, Issue 3, Pages 327-336Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci0214362
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Funding
- NCI NIH HHS [P01 CA045548, CA45548] Funding Source: Medline
- NHLBI NIH HHS [HL-6221] Funding Source: Medline
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The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, their role in retinal vascular development was studied in mice selectively expressing single isoforms. VEGF(164/164) mice were normal, healthy, and had normal retinal angiogenesis. In contrast, VEGF(120/120) Mice exhibited severe defects in vascular outgrowth and patterning, whereas VEGF(188/188) mice displayed normal venular outgrowth but impaired arterial development. It is noteworthy that neuropilin-1, a receptor for VEGF164, was predominantly expressed in retinal arterioles. These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina.
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