Journal
INFECTION AND IMMUNITY
Volume 70, Issue 2, Pages 1010-1013Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.2.1010-1013.2002
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Funding
- NIAID NIH HHS [N01 AI-75320, N01 AI-55262] Funding Source: Medline
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The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.
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