Journal
NEUROSCIENCE LETTERS
Volume 318, Issue 3, Pages 121-124Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(01)02359-X
Keywords
regeneration; artificial material; horseradish peroxidase; central nervous system; artificial nerve; biodegradable material; synaptic connection
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The spinal cord segments at T9-10 were totally excised and the resulting gap was filled by implantation of alginate sponge in adult rats. A horseradish peroxidase-tracing study at 21 weeks after operation showed that numerous ascending and many but less numerous descending regenerating fibres traversed the alginate-filled gap, and that after re-entering the distal stump of the transected spinal cord, they extended randomly over a long distance away from the gap. Intracellular electrophysiological recording at the same postoperative time showed that both ascending and descending regenerating axons formed functional synapses with host neurons located beyond the gap. These findings suggest that alginate could be a promising material for the support of regenerating axons in the spinal cord. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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