Journal
JOURNAL OF NATURAL PRODUCTS
Volume 65, Issue 2, Pages 210-214Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0104020
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Funding
- NCI NIH HHS [CA 36622, CA 67786] Funding Source: Medline
- NCRR NIH HHS [RR06262] Funding Source: Medline
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Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1)/(Cipl)-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 muM, respectively.
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