Journal
MECHANISMS OF DEVELOPMENT
Volume 111, Issue 1-2, Pages 99-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00614-1
Keywords
cell cycle; cyclin D3; p21; cdk6; implantation; polyploidy; decidualization; uterus; mouse
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Funding
- NICHD NIH HHS [HD-29968, U54 HD033994, HD-33994, HD-02528, R01 HD037830, HD-37830, R37 HD012304, P30 HD033994, HD-12304, P30 HD002528] Funding Source: Medline
- NIEHS NIH HHS [ES-07814, R01 ES007814] Funding Source: Medline
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Uterine decidualization, characterized by stromal cell proliferation, and differentiation into specialized type of cells (decidual cells) with polyploidy, during implantation is critical to the pregnancy establishment in mice. The mechanisms by which the cell cycle events govern these processes are poorly understood. The cell cycle is tightly regulated at two particular checkpoints, G1-S and G2-M phases. Normal operation of these phases involves a complex interplay of cyclins, cyclin-dependent kinases (cdks) and cdk inhibitors (CKIs). We previously observed that upregulation of uterine cyclin D3 at the implantation site is tightly associated with decidualization in mice. To better understand the role of cyclin D3 in this process, we examined cell-specific expression and associated interactions of several cell cycle regulators (cyclins, cdks and CKIs) specific to different phases of the cell cycle during decidualization in mice. Among the various cell cycle molecules examined, coordinate expression and functional association of cyclin D3 with cdk4 suggest a role for proliferation and, that of cyclin D3 with p21 and cdk6 is consistent with the development of polyploidy during stromal cell decidualization. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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