Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 643, Issue -, Pages 350-356Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(01)01271-2
Keywords
bioorganometallic; titanocen.; tamoxifen; estrogen; SERM; MCF7; proliferative effect
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The synthesis of 4'. a titanocene derivative of the anticancer drug tamoxifen is presented together with its biochemical properties. Compound 4' is prepared by a McMurry coupling followed by a ligand exchange. Compound 4' reveals an unexpected proliferative effect on the hormone-dependent cell line MCF7. Surprisingly this effect is also observed with Cp2TiCl2 alone. (C) 2002 Elsevier Science B.V. All rights reserved.
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