Journal
EUROPEAN JOURNAL OF CANCER PREVENTION
Volume 11, Issue 1, Pages 19-26Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008469-200202000-00004
Keywords
antioxidants; chemoprevention; gastric carcinogenesis; glutathione; lipid peroxidation; lycopene; N-methyl-N '-nitro-N-nitrosoguanidine
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We investigated the chemopreventive potential of lycopene against gastric carcinogenesis induced in male Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and saturated sodium chloride (S-NaCl). Administration of lycopene inhibited MNNG+S-NaCl-induced gastric carcinogenesis as revealed by the absence of carcinomas. Lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were used to monitor the chemopreventive potential of lycopene. The extent of lipid peroxidation was significantly lower, whereas GSH, GPx, GST and GR were markedly enhanced in the gastric mucosa of tumour-bearing animals. Our data suggest that lycopene may exert its inhibitory effects by modulating the oxidant and antioxidant status in the gastric mucosa. (C) 2002 Lippincott Williams Wilkins.
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