Journal
NEUROSCIENCE LETTERS
Volume 318, Issue 3, Pages 163-165Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02452-1
Keywords
Fast Green FCF; Food Green 3; hippocampus; patch clamp; interneurons; miniature synaptic events
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The effects of the certified food dye Fast Green FCF (Food Green 3) on miniature synaptic events in whole-cell voltage clamped hippocampal interneurons were examined. Fast Green FCF reduced the frequency, but did not affect the amplitude or kinetics, of miniature synaptic events in a dose-dependent manner. At 1 mg/ml (1.2 mM), the frequency was reduced to 21% of control. The half-maximum effective concentration was estimated to be 200 mug/ml (250 muM). In contrast, the dye Phenol Red neither affected frequency, amplitude nor kinetics of synaptic events. The results suggest that Fast Green FCF acts at a presynaptic locus, thereby inhibiting the release of neurotransmitter. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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