Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 13, Issue 1, Pages 52-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0958-1669(02)00284-7
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Intracellular delivery of macromolecules remains problematic because of the bioavailability restriction imposed by the cell membrane. Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive isotopes into cells in culture and animal models in vivo.
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