Journal
GENETICAL RESEARCH
Volume 79, Issue 1, Pages 85-96Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0016672301005389
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM 45344] Funding Source: Medline
Ask authors/readers for more resources
Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based oil sex-specific linkage maps.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available