Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 14, Issue 1, Pages 18-24Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(01)00289-7
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The past several years have seen major advances in our understanding of the mechanisms of microtubule destabilization by oncoprotein 1 8/stathmin (Op 1 8/stathmin) and related proteins. New structural information has clearly shown how members of the Op 1 8/stathmin protein family bind tubulin dimers and suggests models for how these proteins stimulate catastrophe, the transition from microtubule growth to shortening. Regulation of Op1 8/stathmin by phosphorylation continues to capture much attention. Studies suggest that phosphorylation occurs in a localized fashion, resulting in decreased microtubule destabilizing activity near chromatin or microtubule polymer. A spatial gradient of inactive Op1 8/stathmin associated with chromatin or microtubules could contribute significantly to mitotic spindle assembly.
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