Synthesis and biological evaluation of new antimalarial isonitriles related to marine diterpenoids

By exploiting the chemistry of arene tricarbonylchromium(0) complexes. sonic analogues of antimalarial marine isonitrile diterpenoids were synthesized in a completely diastereoselective fashion and their activity against the malaria parasite Plasmodium falciparum was assessed in an in vitro assay. (C) 2002 Elsevier Science Ltd. All rights reserved.