Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 767, Issue 1, Pages 159-162Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-4347(01)00547-3
Keywords
sulfadoxine; pyrimethamine
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A method using solid-phase extraction and high-performance liquid chromatography is evaluated for the simultaneous determination of sulfadoxine and pyrimethamine from 0.1 ml of whole blood dried onto filter paper. Extraction recoveries are about 60% for both drugs. The coefficient of variation for intra-assay precision, inter-assay precision and accuracy is less than 10% for sulfadoxine (10-100 mug/ml) and pyrimethamine (1-10 mug/ml). Published by Elsevier Science B.V.
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