Journal
BRAIN RESEARCH
Volume 927, Issue 1, Pages 8-17Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(01)03309-1
Keywords
fragile X syndrome; Fmr1; knockout mouse; prepulse inhibition; acoustic startle response; startle habituation; C57BL/6J; FVB
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Funding
- NICHD NIH HHS [HD 17449, HD 04024] Funding Source: Medline
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Fragile X syndrome results from inadequate production of the fragile X mental retardation protein (FMRP). Mice with a mutation targeted to the Fmr1 gene lack FMPP and thus are a valuable animal model for studying the behavioral and neural phenotype of this human disorder. Mice of two genetic backgrounds containing the Fmr1 mutation, C57BL/6J (C57-KO) and an F1 hybrid (C57BL/6J mutant x FVB/NJ; F1-KO) did not differ from control mice in behavior in the elevated plus maze or the open field. Both the C57-KO and F1-KO mice exhibited greater startle responses than normal mice to low intensity (80 dB) white noise bursts and decreased responses to high intensity ( 120 dB) white noise bursts. These behavioral alterations appear to be specific to the Fmr1 mutation since they are present on both genetic backgrounds. Furthermore, the mice lacking FMRP resemble individuals with fragile X syndrome in their increased sensitivity to low intensity auditory stimuli. These findings should prove useful in determining how the absence of FMRP alter's the brain and behavior, and in testing potential treatments for fragile X syndrome. (C) 2002 Elsevier Science BY. All rights reserved.
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