Tetra-n-butylammonium fluoride:: an efficient base for aza-Michael addition -: synthesis of glycosyl β-amino acid esters

A mild and efficient route to glycosyl beta-amino acid esters. exploiting the stereoselective Michael addition of benzylamine, in the presence of tetra-n-butylammonium fluoride, to sugar derived gamma-alkoxy alpha,beta-unsaturated esters is described. (C) 2602 Published by Elsevier Science Ltd.