Journal
AIDS
Volume 16, Issue 3, Pages 486-488Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200202150-00023
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Thirty-nine HIV-1-infected men were prospectively tested for HIV seminal shedding after the initiation of highly active antiretroviral therapy. HIV RNA drastically decreased in the semen of all men, but low levels remained detectable in three men at month 18. Proviral HIV DNA became undetectable in the seminal cells of all men after 18 months. HIV-infected cells in the male genital compartment may come from the intermittent passage of blood lymphocytes, rather than constituing a major local reservoir.
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