Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1553, Issue 3, Pages 188-211Publisher
ELSEVIER
DOI: 10.1016/S0005-2728(02)00185-8
Keywords
ATP synthesis; oxidative phosphorylation; F1F0-ATP synthase; molecular mechanism; catalytic site; subunit rotation
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Funding
- NIGMS NIH HHS [GM25349] Funding Source: Medline
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ATP synthesis by oxidative phosphorylation and photophospliorylation. catalyzed by F1F0-ATP synthase, is the fundamental means of cell energy production. Earlier mutagenesis studies had gone some way to describing the mechanism. More recently, several Xray structures at atomic resolution have pictured the catalytic sites, and real-time video recordings of subunit rotation have left no doubt of the nature of energy coupling between the transmembrane proton gradient and the catalytic sites in this extraordinary molecular motor. Nonetheless, the molecular events that are required to accomplish the chemical synthesis of ATP remain undefined. In this review we summarize current state of knowledge and present a hypothesis For the molecular mechanism of ATP synthesis. (C) 2002 Elsevier Science B.V. All rights reserved.
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