Journal
DRUG DISCOVERY TODAY
Volume 7, Issue 4, Pages 235-246Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(01)02131-6
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G-protein coupled receptors (GPCRs) represent possibly the most important target class of proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor family. These drugs exhibit their activity at <10% of all known GPCRs. A major challenge for the pharmaceutical industry is to associate the many novel GPCRs with disease to identify the drugs of the future. This process consists of a collection of experimental paradigms that together can be loosely labelled 'target validation'.
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