Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1559, Issue 2, Pages 179-185Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2736(01)00449-7
Keywords
sodium glucose cotransporter; GLUT2; rat jejunum; cyclic AMP
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We have investigated the effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively. Forskolin treatment increased SGLT1 but decreased GLUT2 expression in mid and lower villus enterocytes. No change in transporter expression was noted in upper villus cells. Likewise, cyclic AMP levels were raised in mid and lower but not upper villus cells, The implications of these data for glucose transport are discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
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