4.4 Article

Indium-mediated facile cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate

Journal

TETRAHEDRON LETTERS
Volume 43, Issue 8, Pages 1549-1551

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)02374-7

Keywords

indium; carbamates; sulfonamides; alpha-amino acids

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Di-t-butylimidodiacarbonates are selectively and efficiently deprotected to the corresponding mono-BOC protected amines in high yields using indium or zinc metal in refluxing methanol. Simple BOC and CBz protected amines are unaffected by these conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

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